Cytotoxic and Antimicrobial activity of Diketopiperazines from Unidentified Marine-Derived Fungus

Wilmar Maarisit

doi:10.55724/jis.v4i1.69

Wilmar Maarisit Program Studi Farmasi, Fakultas MIPA, Universitas Kristen Indonesia Tomohon

DOI: https://doi.org/10.55724/jis.v4i1.69

Keywords: Bioactive metabolites, marine-derived fungi, cytotoxic, antimicrobial, diketopiperazines

Abstract

Two new diketopiperizines 1 and 2 were isolated together with a known diketopiperazine cis-bis(methylthio)-silvatine (3) and a known 5a,8a-epidoxy-(22E,24R)-ergosta-6,22-dien-3b-ol(ergosterol peroxide) (4) from a marine-derived fungus. The structures of 1-4 were elucidated by 1D and 2D NMR analyses. Cytotoxicity of the isolated compounds against human colorectal cancer cell lines (HCT116) and their antibacterial and antifungal activities were evaluated.